The Safest Medicine on Earth? CBD’s Low Toxicity

Posted by Desiree Jones on

Is cannabidiol safe to ingest? Are there any risks? A quick look at the safety of CBD.

You can pick up CBD while you’re pumping your gas.

When you grab a movie for date night, you can throw a bottle of CBD oil in with it at the register.

Beauticians can rub CBD into their skin, insomniacs can vape it before bed, anxious people can eat it for breakfast.

CBD Oil Lotion

CBD products are everywhere and they’re helping people in a multitude of ways.

That has some people wondering about the safety of CBD.

The Toxicity of CBD

In 2019, researchers wanted to look at the toxicity levels of CBD. To do so, they reviewed a number of relevant animal studies.

According to the research, which was published in the journal, Current Neuropharmacology, animals showed the following negative reactions to CBD:

  •       Developmental toxicity
  •       Embryo-fetal mortality
  •       Central nervous system inhibition and neurotoxicity
  •       Hepatocellular injuries
  •       Spermatogenesis reduction
  •       Organ weight alterations
  •       Male reproductive system alterations
  •       Hypotension

Don’t be too alarmed, however. When these conditions occurred, it was “at doses higher than recommended for human pharmacotherapies.”

A 2017 study, which was published in the journal, Cannabis and Cannabinoid Research, had formerly reviewed the safety of human consumption.

The authors, Iffland and Grotenhermen, succinctly noted that “the often described favorable safety profile of CBD in humans was confirmed and extended by the reviewed research.”

However, that doesn’t mean that consumption doesn’t come without some risks.

Risks of CBD Consumption

According to the same 2017 article, there isn’t much known about how CBD impacts hormones over the long term, for example.

Studies like this (and many more) have yet to be performed, so there may be some risks that CBD presents that have yet to manifest themselves in the research.

However, in the 2019 study, Huestis et al. found that some risks have already been determined.

For example, there is a risk of negative drug-drug interactions when using CBD.

Moreover, the researchers found that there is some chance for:

  •       Hepatic abnormalities
  •       Diarrhea
  •       Fatigue
  •       Vomiting
  •       Somnolence

Importantly, negative side effects are rare and often appear when consuming high doses.

Developing a Tolerance to CBD


Thankfully, according to the 2018 research published in Frontiers in Pharmacology, humans don’t develop a tolerance to CBD as they do THC.

Once consumers find their minimum threshold for consumption, they don’t have to worry about increasing it to potentially risky levels.

The Worst Part of CBD is Deciding Which Product to Purchase

While research continues to expand every day in this burgeoning industry, most experts agree: CBD has relatively low levels of toxicity and is generally safe for human consumption.

There’s no need to fear CBD, which is exactly why there are now so many products readily available.

If you know someone who has been asking about CBD who would benefit from this guide, please share it with them!


By Nicholas D. 

Professional Cannabis Writer and Content Creator

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